Match each checkpoint with the action it checks for. Checks whether the microtubules have attached to the centromeres of the chromosomes checks for cell size and DNA damage checks whether DNA has doubled and repairs it if damaged

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Answer:

The cell cycle is mainly regulated with the help of three checkpoints: G₁ checkpoint, G₂ checkpoint, and M checkpoint.

G₁ checkpoint checks for

  • Size of the cell
  • Nutritional availability
  • Growth factors and
  • DNA (deoxyribonucleic acid) damage.

Hence, it can be correctly matched with checks for cell size and DNA damage.

Only after passing through this check point the cell enters the S or synthesis phase where the DNA content is doubled.

The G₂ checkpoint is present between G₂ phase and M phase. It checks the cell for its protein reserves as well as if the DNA has replicated accurately or not.

If cell passes this checkpoint then it enters into the M phase.

Hence, it can be correctly matched with checks whether DNA has doubled and repairs it if damaged

Lastly, the M checkpoint checks if spindle microtubules are properly attached to the centromeres of all the chromosomes.

This checkpoint allows the progression from metaphase to anaphase.

Hence, it can be correctly matched with microtubules have attached to the centromeres of the chromosomes.

G₁ checkpoint checks for cell size and DNA damage, G₂ checkpoint whether DNA has doubled and repairs it if damaged and M checkpoint checks if microtubules have attached to the centromeres.

Cell cycle and checkpoints

The cell cycle refers to the events that occur in a given cell as it grows and divides.

  • The cell cycle can be divided into interphase, which is in turn divided into G1, S and G2 phases, and a mitotic M phase.

  • Cell cycle checkpoints refer to specific points in which the cell checks if all is correct to progress through the cell cycle.

In conclusion, G₁ checkpoint checks for cell size and DNA damage, G₂ checkpoint whether DNA has doubled and repairs it if damaged and M checkpoint checks if microtubules have attached to the centromeres.

Learn more about the cell cycle here:

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