Respuesta :
Answer:
The effect of arsenic poisoning result in the loss of ATP molecules.
Explanation:
Arsenate structurally resembles the phosphate group.In the reaction catalyzed by glyceraldehyde-3-phosphate dehydrogenase,arsenate can replace the phosphate group by attacking the energy rich thioester intermediate resulting in the formation of 1-arseno-3-phosphoglycerate which is unstable and undergo hydrolysis to form 3-phosphoglycerate.
As a result the glycolytic pathway continues but the ATP that is normally generated from 1,3-bisphosphoglycerate by substrate lebel phosphorylation is lost due to the interference of arsenate.
Arsenite is a derivative of arsenate that interacts with lipoic acid coenzyme of pyruvate dehydrogenase enzyme thus blocking the formation of acetyl CoA which ultimately leads to loss of ATP molecules.
